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"And when these two things become conflated, it becomes really difficult for people to discern [if] this is a conversation about health, or a conversation about how good we look?" Industries, she said, were capitalising on this confusion

Feng P, Zhang X, Li D, et al

Weight loss specialists generally avoid this combination due to safety risks and lack of clinical trial data supporting its use

The results of a meta-analysis indicate that GLP-1RAs can reduce major adverse cardiovascular events (MACE) such as cardiovascular death, stroke, or myocardial infarction, as well as hospital admissions for heart failure and all-cause mortality, in patients with T2D [44]

Patients included in the trial had HbA1c 7 to 10% and were treated with either: diet and exercise alone or 1 to 3 oral antidiabetic drugs (metformin, sulfonylurea, glitazone or sodium-glucose co-transporter 2 inhibitor)

It has not received marketing authorisation from the MHRA or EMA and is not approved for clinical use in the UK