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Market Opportunities Use of GLP-1 Therapies in Metabolic Dysfunction and Development of Next-generation Oral & Combination Incretin Therapies Offer Growth Opportunities to Market Players The growing clinical potential of GLP-1 receptor agonists in treating MASH is creating significant opportunities for pharmaceutical manufacturers and biotechnology companies

Discussion Current evidence strongly supports the efficacy of GLP-1 receptor agonists for inducing substantial weight loss, improving metabolic control, and reducing cardiovascular risk often surpassing the short-term effects of exercise alone (410, 23)

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Bowel obstruction in patients receiving GLP-1 RAs has been reported in several studies [10,16,17], without other contributing antimotility agents