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The primary concern relates not to direct drug interactions between most injectable GLP-1 agonists and levothyroxine, but rather to the potential impact on thyroid monitoring and the theoretical risk associated with thyroid C-cell tumours observed in animal studies

Gorgojo-Martnez JJ et al

Constipation symptoms have been reported to last longer than those of the other GI AEs

Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor

Explore GLP-1 Medications: Mechanisms and Benefits Glucagon-like peptide-1 (GLP-1) treatments represent a significant advancement in managing type 2 diabetes and promoting weight loss