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A novel basket trial design simultaneously evaluates retatrutide treatment across these multiple adiposityrelated disease states

GLP-1 analogues are generally not recommended during pregnancy or breastfeeding due to limited safety data in these populations

Summary Non-small cell lung cancer (NSCLC) presents persistent challenges in immunotherapy, as the clinical benefit of programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors is frequently constrained by intrinsic and acquired resistance

AKT, an effector molecule downstream of PI3K activation, is widely involved in the biological processes of the PI3K/AKT pathway

The study is enrolled and 80% of the patients have completed six months of observation

14 , e00578 (2023)