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Description
Semaglutide (Wegovy, 2.4 mg weekly), STEP-1, 68 weeks: mean weight loss approximately 14.9%
Nausea was reported in approximately 4060% of participants receiving mid-to-high doses (8 mg and 12 mg) in the Phase 2 NEJM 2023 trial
To protect lean mass during rapid weight loss, aim for 1.2 to 1.6 grams of protein per kilogram of body weight daily
Regular activity, even mild, makes it easier to keep weight off
Eating small, nutrient-dense mealseven when appetite is suppressedensures adequate electrolytes (sodium, potassium, magnesium), which stabilize inner-ear function and blood pressure
UW Medicine
