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In SURPASS-3, those taking tirzepatide achieved an HbA1c of less than 7% in a median of 8.1 weeks compared with 12.1 weeks in those taking insulin degludec

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Insulin resistance contributes to the downregulation of muscle contractile protein synthesis by inhibiting insulins anabolic signaling pathway and simultaneously upregulating protein degradation via the ubiquitinproteosome pathway [30]