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When metabolic stress hits the cell (low energy, high oxidative load, glucose imbalance), MOTS-c is released from the mitochondria, enters the cytoplasm, and ultimately translocates into the cell nucleus where it regulates expression of stress-adaptation genes

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This chronic condition is associated with cardiovascular diseases, type 2 diabetes, several cancers, and respiratory conditions, driving high rates of morbidity and mortality [1,2,3]
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