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Several studies have shown that depressed patients have impaired gut-brain axis metabolism, appetite disturbances, and gut hormone abnormality (Collins and Bercik, 2009

Fatigue and cognitive fog tend to become pronounced by day three or four as glycogen stores deplete and the body struggles to find stable fuel in the absence of fat or protein

The warmth is the physiological signature of that additional mechanism

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"In some cases, it may cause more side effects." However, Ozempic pens don't need to be kept in the fridge forever

Once those are in control, conversations can be had with your healthcare team about reducing some medication, if appropriate
