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Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats

Those positive estimates also rest largely on the early-phase studies, and the single most heavily weighted Phase 3 result, the null Exenatide-PD3 trial, argues against a robust class-wide effect
They acknowledged that while the link between GLP-1 drug use and fertility improvement is encouraging, the studys sample size was relatively small, and longer-term effects remain unknown

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