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Berberine is a chemical compound extracted from plants like goldenseal and barberry and often sold as a supplement, typically in capsules filled with yellow-tinged powder

Renal elimination of unchanged orforglipron is minimal, suggesting that dose adjustment in patients with renal impairment may not be necessary

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Polanski JF, Soares AD, de Mendonca Cruz OL

But context matters more

For Novo and Lilly, its a tradeoff: lower prices for higher patient and prescription volume a bet that should pay off over time, especially since tariff relief is part of the deal