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Emerging role of GLP-1 agonists in obesity: A Comprehensive review of randomised controlled trials

It set a target audience to specific exercises and checked body fat levels, showing that even with very targeted exercises, the fat loss was not targeted

2014,76 Pt B:3519

Trial participant reports While not systematic data, reports from TRIUMPH trial participants provide additional context: Evidence: Community-reported One TRIUMPH-1 participant reported losing 30.6% of body weight (approximately 75 pounds) after one year on the trial, going from XL/2XL shirts to medium and fitting into size 32 pants for the first time in 20 years The same participant reported cholesterol down 30-33%, triglycerides down 70%, blood pressure normalized, fatty liver disease resolved (confirmed by CT scan), and asthma symptoms eliminated These individual results are consistent with the upper range of clinical trial outcomes and should not be taken as typical Beyond Weight Loss: Other Results TRIUMPH-4 measured outcomes beyond the scale: Cardiovascular markers Knee osteoarthritis outcomes (TRIUMPH-4 specific) Liver fat (Phase 2 sub-study) A sub-study of the Phase 2 trial measured liver fat by MRI and found reductions of up to 82.4% at the highest dose among the strongest liver fat reduction results for any drug in development

In a case report, semaglutide was proved highly effective against severe psoriasis in a T2DM patient showing improvement in PASI, DLQI as well as in HbA1c and BMI [153]