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Its brand names include Wegovy, tailored specifically for weight management, and Ozempic, approved for type 2 diabetes

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Before determining that a shortage is resolved, FDA considers a variety of factors, including the companys ability to meet current and historical demand, the amount in a manufacturers stock, affected market share, ability of alternate manufacturers to cover the demand, and confirmed market stabilization

Mechanistically, ketogenic metabolic therapy has been proposed to i) enhance mitochondrial biogenesis and energy efficiency, ii) reduce oxidative stress and systemic inflammation, iii) modulate glutamatergic neurotransmission and iv) increase BDNF expression and neuroplasticity