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Recently, in addition to the central maintenance of food intake, GLP-1R signaling has begun to be considered in the context of the regulation of the stress response, as it is indicated that it can activate both the hypothalamicpituitaryadrenal (HPA) axis as well as the sympathetic nervous system [15, 16]

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A smaller Phase II trial in diabetics showed 16% weight loss after 32 weeks, fueling hopes for stronger results in a longer Phase III study