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Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

Long-term adherence is essential to realizing the full therapeutic potential of GLP-1s, yet behavioral factors (such as reaching personal weight goals or perceived social stigma) and systemic issues (like high out-of-pocket costs and fragmented care) disproportionately affect obesity patients

-1GLP-12

Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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