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GLP-1 RA microdosing uses doses below the smallest available commercial threshold typically starting at 0.1250.25 mg semaglutide weekly and often extends dosing intervals to every 10, 14, 21, or 28 days

19 Dei CasA.MicheliM.AldigeriR.GardiniS.Ferrari-PellegriniF.PeriniM.et al (2024)

As such, the GLP-1 pathway has become a major therapeutic target in diabetes, obesity, and cardiometabolic research

The progression of semaglutide from a metabolic drug to a potential neuroprotective agent is ongoing, but its future role in neurology will likely focus on the prevention of neurodegeneration rather than the treatment of established diseases

Both target pathophysiology contributing to psychiatric symptoms