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Procedures Participants were categorized by degree of weight regain from week 36 to week 88 after tirzepatide withdrawal

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While some people taking these drugs experience difficult side effects, including nausea, vomiting and diarrhoea and there is a need for more data on the impact of long term use of these medicines, currently available data suggest the benefits associated with them outweigh their risks

The gradual dose titration for both medications is designed to minimise these effects

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GLP-1 receptor agonists are highly effective medications that mimic the GLP-1 hormone to regulate blood sugar, slow gastric emptying, and increase satiety