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Exp Cell Res (2017) 360(2):28191

The underlying mechanism of this phenomenon was down-regulation of ACAT1 and CD36 and ABCA1 up-regulation

The first precursor to Ozempic and Mounjaro came out 20 years ago

Studies of both mice and humans show the anti-inflammatory effects (such as reductions in TNF-) occur within hours, suggesting some actions are independent of weight loss or long-term metabolic change

Tirzepatides dual GLP-1R and GIPR agonism may confer distinct anti-inflammatory effects, some of which persist even when neuronal GLP-1R signaling is impaired

GLP1 Receptor Agonists-Effects beyond Obesity and Diabetes
