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GLP-1 RA glucagon-like peptide 1 receptor agonists, CI confidence interval, MACE major adverse cardiovascular event, MI myocardial infarction, SBP systolic blood pressure in mmHg, HR hazard ratio, RR relative risk, HF heart failure, LVEF left-ventricular ejection fraction a Primary or secondary outcome of interest as reported by the study Statistically significant confidence interval Major Adverse Cardiac Events Among Patients with T2DM Strong evidence supports using GLP-1 RAs to reduce MACE among patients with T2DM and established CVD

But Point32Healths executive chair, Eileen Auen, last month said the insurer planned to make Zepbound its preferred exclusive GLP-1 drug for the treatment of obesity, starting in July
However, the agonist liraglutide induced higher upregulation of GLP-1R compared with that in the LPS group
Mild side effects may occur frequently with dose increases but become less noticeable over time 5
