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The role of tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: the SURPASS clinical trials

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Notably, the PKA inhibitor 8-Br-Rp-cAMPS attenuates the inhibitory effect of GLP-1 on glucagon secretion, suggesting that GLP-1 suppression of glucagon secretion is PKA-dependent [583]

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[DOI] [PubMed] [Google Scholar] 198.Ahlqvist E., Storm P., Karajamaki A., Martinell M., Dorkhan M., Carlsson A

Specifically, they proposed an approach in which GLP-1RAs could be prescribed for an initial period of weight loss before patients transitioned to cheaper alternative interventions for weight maintenance such as lower-cost medications, behavioral health programs and support from nutritionists