surmount-1 trial tirzepatide weight loss nondiabetic Gastrointestinal tolerability and reduction associated with in adults with obesity or overweight with and without type 2 diabetes in the SURMOUNT‐1 to ‐4 trials - Rubino - 2025 SURMOUNT-1: Adults achieve weight loss

Detailed Clinical Takeaways boxes are available in the Supplementary Material

This slow build exists for good reason

Start with the plain answer, then add the caveat that changes the decision: cost, coverage, safety, provider oversight, pharmacy source, or whether the claim can be verified

September 2022

Available medications Tirzepatide Pricing Promo rate$299/mo* Flat rate$399/mo *For patients starting at the lowest dose if prescribed Semaglutide Pricing Promo rate$199/mo* Flat rate$299/mo *For patients starting at the lowest dose if prescribed Zepbound Pricing 2.5 mg$299/mo 5 mg$399/mo 7.5 15 mg$449/mo Requires Sculpt Rx membership ($89/month)

The research base draws on Phase 2/3 trials, mechanistic studies, and metabolic outcomes research across multiple institutions