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In these cardiovascular safety trials, in secondary or exploratory analyses, GLP-1 receptor agonists were also shown to reduce macro-albuminuria, an accepted surrogate marker for diabetic kidney disease (DKD), a condition that still represents a major unmet medical need

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Semaglutide restored GSK3-Drp1 signalling, maintained mitochondrial membrane potential, and decreased mitochondrial fragmentation in primary cardiomyocytes via GLP-1R activation