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Studies show that losing just 10% of body weight can result in up to 20% reduction in facial fat volume, particularly affecting the mid-face region

[1] In STEP UP trial data, average weight loss at 72 weeks was greater with semaglutide 7.2mg than with 2.4mg, but trial averages do not predict an individual result

Methods In this prospective, randomized cohort, adults between the ages of 18 and 65, with a BMI of at least 27 kg/m, were assigned to one of two treatment groups: IGB only or IGB + semaglutide

Understanding tirzepatide's synthetic origin and mechanism helps clinicians optimize its use in appropriate patient populations

Tirzepatide-associated starvation ketoacidosis

Semaglutide activates GLP-1 receptors only, while tirzepatide is a dual GIP/GLP-1 receptor agonist, activating two complementary pathways involved in blood sugar regulation and appetite control