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Cresci B, Cosentino C, Monami M, Mannucci E (2020) Metabolic surgery for the treatment of type 2 diabetes: a network meta-analysis of randomized controlled trials

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GIPR has been demonstrated to undergo significant functional desensitization, internalization, and downregulation, with severely desensitized capacity to produce cAMP in transfected cells, as well as in primary adipocytes, neuronal cells, and pancreatic islet cells in vitro [43]

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For instance, Ke Cheng et al loaded FGF-2 and FGF-21 into microneedle patches made from hyaluronic acid (HA) hydrogel, observing significant improvement after 4 weeks of treatment