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Contact your GP or healthcare provider if you experience: Persistent or severe abdominal or flank pain that differs from typical Wegovy side effects or does not resolve with simple analgesia Blood in your urine (visible or detected on urine testing) Difficulty passing urine or a significant decrease in urine output Severe or persistent nausea and vomiting that prevents adequate fluid intake or leads to signs of dehydration (dizziness, dry mouth, reduced urine output, dark urine) Unexplained fever alongside urinary symptoms or flank pain, which may indicate infection Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe, uncontrollable pain that is not relieved by over-the-counter painkillers High fever (above 38C) with rigors (shaking chills) alongside urinary symptoms, suggesting possible sepsis Complete inability to pass urine , which may indicate urinary obstruction Signs of severe dehydration , including confusion, rapid heartbeat, or fainting Fever with suspected kidney stone obstruction , which requires urgent assessment as per NICE guideline NG118 For non-emergency but urgent concerns, you can also contact NHS 111 for advice

This leads to improved insulin resistance and pancreatic beta-cell function, which decreases deposition of lipid metabolites in adipose and extra-adipose tissue such as skeletal muscles and liver and corrects the impaired adipose tissue signaling [38]

Bile acids , secreted from the gallbladder upon eating, robustly activate a series of metabolic hormones including GLP-1 (Zietek, et al., 2018)

Check Our Offers Table of Contents: What are the benefits of using GLP-1 for medical weight loss

Around two months into treatment many patients report steadier appetite control and improved eating habits

2023;doi:10.1007/s11739-023-03237-4 Marx J