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In a 2-year study dapagliflozin did not significantly affect bone mineral density at the lumbar spine, femoral neck, or total hip (228)

Example: A patient taking a daily GLP-1 at 08:00 should skip the dose scheduled for the morning before a noon surgery and report the skipped dose to the surgical team

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For patients whose primary goal is metabolic wellness, appetite regulation, or a gentler introduction to dual-receptor therapy rather than maximum weight loss, that trade-off often makes sense