how was tirzepatide discovered - an overview Tirzepatide - Wikipedia
Description
In this paper, the authors describe the energy state-dependent regulation of the PVNGLP-1R to DVC circuit, resulting in altered food intake and metabolic health, mediated by GLP-1 receptor signalling.
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I was expecting to see more GI side effects with the higher dose, but it wasn't too much higher--70.8% at 7.2 mg vs 61.2% at 2.4 mg vs 42.8% with placebo, mostly mild an self-limited
