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Patients switch because of efficacy, tolerability, access, cost, insurance coverage, or newer options becoming available

Trial registration ClinicalTrials.gov NCT05071950

Additionally, these are not components of FDA-approved drugs and have not been found safe and effective for any condition.At this time, these drugs are only legally accessible to clinical trial patients

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Despite their established glucose-lowering effects, there is no consensus among global experts and modern guidelines regarding the priority of SUs in relation to other therapeutic options, given the lack of evidence that SUs are associated with a low risk of macrovascular events and excess mortality