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Real-world outcomes from clinical practices align closely with these trial results, though individual variation remains significant

SUSTAIN 2: Demonstrated superiority to sitagliptin (DPP-4 inhibitor) in HbA1c reduction and comparable weight loss [8]

This finding is clinically meaningful because it suggests that the risk may accumulate over time. Given that many individuals use these medications chronically, whether for blood sugar control or for weight loss, the long-term ocular safety of GLP-1 RAs requires further investigation, he continued

Mazdutide availability Mazdutide received approval in China in June 2025, marketed under the brand name Xinermei by Innovent Biologics

Longer term For longer protocols, review cardiovascular and mood-related context periodically with a clinician

Many patients find these drugs to be life changing