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Importantly, it has been demonstrated that a deficiency in brain pericytes in murine central nervous system lead to vascular damage through a reduction in brain microcirculation as well as via BBB breakdown with toxic extravasation of plasma proteins ( Several molecular changes have been linked to the vascular dysfunction and disruption of the BBB in AD
Glucagon influences energy balance in order to modulate body weight via facultative thermogenesisincreased heat production primarily in brown adipose tissue (BAT) and skeletal muscle when heat-saving mechanisms such as piloerection cannot maintain body temperature within a physiologic range [86]
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Annual initiation prevalence was calculated for each eligible BMI subgroup
