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Anorexigenic lipopeptides ameliorate central insulin signaling and attenuate tau phosphorylation in hippocampi of mice with monosodium glutamate-induced obesity

To our knowledge, we are one of the few groups working on defining how weight-loss drugs directly impact the function of innate and adaptive immune cells

a The World Health Organization and the World Obesity Federation use the term obesity to describe having a body mass index (BMI) of 30 kg/m 2 or greater

(9, 11) At the metabolic level, the signaling cascades that regulate bone metabolism offer some explanation for the obesity paradox

Microdosing follows a research-supported model that uses lower initial concentrations of GLP-1 compounds to minimize gastrointestinal side effects while maintaining metabolic benefits

Nausea is typically most pronounced during dose initiation and escalation, generally improving over 24 weeks as physiologic adaptation occurs