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Results 101 randomized controlled studies were included in final analysis, with 41,443 of 57,684 patients receiving one of five GLP-1 RAs: liraglutide (37 studies), semaglutide (28 studies), exenatide (25 studies), dulaglutide (18 studies), and tirzepatide (8 studies)

Effectiveness and Impact Significant Weight Loss: Phase 2 studies showed up to roughly 20% average body weight loss at 52 weeks in participants with obesity

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Ensure that you leave the needle injected long enough to release all of the medication once you have pressed down on the plunger - 5-6 seconds should be enough

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Most side effects are gastrointestinal in nature and tend to be most noticeable during the dose escalation phase