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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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A collaborative study carried out by the team "Functional Pharmacology and Physiopathology of Membrane Receptors" led by Dr Ralf Jockers, and published in Nature Metab., shows that mutations of the gene encoding the receptor of glucagon-like peptide 1 (GLP1R) affect metabolic traits such as glucose and body weight management and modulates the effectiveness of GLP1R agonists clinically used to treat diabetic and/or obese patients.

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On September 19, 2025, the FDA issued Import Alert 66-80, which authorizes field staff to detain without physical examination shipments of GLP-1 active On September 19, 2025, the FDA issued Import Alert 66-80, which authorizes field staff to detain without physical examination shipments of GLP-1 active pharmaceutical ingredients (APIs) from manufacturers not included on its newly established "Green List.