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Description
Short-acting agents retain their gastric inhibitory effects as they cause only intermittent exposure to pharmacologic concentrations of GLP-1 receptor agonists [48, 53]

Studies indicate that GLP-1R activation exerts anti-inflammatory effects on macrophages, reduces endothelial dysfunction, and inhibits smooth muscle proliferation

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Pramlintide as an adjunct therapy in patients with type 2 diabetes
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