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52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA

[2] [7] These findings led regulatory authorities, including the Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA), to include specific warnings and precautions in the prescribing information for all GLP-1 medications

While tirzepatide has demonstrated a generally favorable safety profile in clinical trials, specific considerations apply when treating patients with autoimmune thyroid disease and hypothyroidism

Tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist that works through similar but expanded mechanisms

Mitochondria as a target and central hub of energy division during cold stress in insects

Contemporary Endocrinology Review, 18 (5), 210225