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Key Facts Challenging the Brain-Centric Model : Clinical trials have long yielded contradictory data regarding GLP-1 drugs, with some showing antidepressant qualities and others hinting at mood liabilities

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Energy production stays high

Patients often face months of denials, step therapy requirements, and exhaustive documentation before any authorization
However, recommended discontinuation intervals vary widely from 1 day to 1 week before elective surgery [74]

Key Highlights: Non-inferior for MACE-3 (CV death, MI, stroke): HR 0.92 All-cause mortality 16% (HR 0.84
