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Description
GLP-1 receptor agonists reduce appetite and slow gastric emptying, creating a caloric deficit that leads to fat mobilisation throughout the body

The first mechanism involves activation of cAMP and PI-3 K pathways via GLP-1R [54]

In contrast, long-acting GLP-1RA has a less pronounced effect on gastric emptying over time due to tachyphylaxis [72] but yields more significant and consistent weight loss [71]

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[DOI] [PubMed] [Google Scholar] 144.Larraufie P., Roberts G.P., McGavigan A.K., Kay R.G., Li J., Leiter A

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