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Each 1 percentage point weight gain after GLP-1 discontinuation was tied with a 2.3% higher likelihood for therapy reinitiation among adults with type 2 diabetes and 2.8% higher odds for restarting a GLP-1 for those without type 2 diabetes

Mean ratings (AUC 15300 min /285 min), maximum ratings and 15-min postprandial ratings were statistically significantly and similarly increased with liraglutide 1.8 and 3.0 mg compared with placebo for overall appetite score (indicating reduced appetite), satiety, fullness and 100-prospective food consumption (indicating reduced prospective consumption)

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By having clear positioning, manufacturers can differentiate their product and potentially achieve a pricing premium

And there are now some interesting observational data

The heartburn was affecting sleep and making mealtimes dreaded