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[15] [37] [38] In August 2025, the Food and Drug Administration (FDA) expanded the indication for semaglutide (as Wegovy) to include the treatment of noncirrhotic metabolic-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) in adults

[61] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels

They work best when paired with healthy habits like balanced eating, regular movement, and ongoing checkins with a healthcare provider to make sure progress stays safe and sustainable

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Are my liver, kidney, blood sugar, or gallbladder markers a concern

The truth is simple: our bodies evolved for survival, not for modern life