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Lastly, upon streptozotocin-induced destruction of the -cells, there is an acute increase in islet PCSK1 and Gcg expression and increased processing of proglucagon to GLP-1 [158]

however, the precise mechanisms are still under investigation

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In alcohol tests in which Ex4, liraglutide, or dulaglutide was injected repeatedly, there was no development of tolerance toward the GLP-1R agonists tested (Suchankova et al., 2015