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These enzymes play a role in converting arachidonic acid into compounds like prostaglandins, thromboxanes, and prostacyclins, which are responsible for signaling pain, causing inflammation, and regulating body temperature

Medical research has established that GLP-1 treatment, under medical surveillance, may result in significant weight loss and some enhancement in some metabolic parameters.Like any other prescription drug, these treatments have side effects and are not applicable to all patients

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For more details regarding LoCITT, including how to participate in this or subsequent trials, please visit The study team will host a webinar on November 5, 2025, 11 a.m

Western blotting results showed that 2,3-cGAMP promoted chondrocyte ferroptosis and the release of TNF- and IL-6 by up-regulating STING expression, p-TBK1, p-IRF3 and down-regulating GPX4 expression, however, this trend could be reversed by C-176 or GLP-1RAs (Fig