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The Phase 3 trials (SYNCHRONIZE-1 and SYNCHRONIZE-2) are fully enrolled

Obesity, unexplained weight loss and suicide: the original whitehall study

Initial observational signals from 2011 suggested an increased risk of acute pancreatitis and pancreatic cancer in patients using GLP-based therapies compared to non-users (adjusted odds ratio [OR]: 2.24, 95% CI 1.36, 3.68), 67 , 68 leading the FDA to issue a warning on the pancreatic safety of GLP-1 RAs

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Effects of intermittent fasting on cardiometabolic risk factors in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials