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In the SURMOUNT-1 clinical trial, participants receiving 15 mg of tirzepatide weekly lost an average of 22.5% of their body weight over 72 weeks

For a comprehensive side effect overview, see our tirzepatide side effects guide

This news comes as the national shortage of the popular glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) medications has improved, prompting the FDA to revisitand ultimately tightenits guidelines around the compounding of these drugs

Injecting there increases the risk of hitting a blood vessel, which causes bruising, or irritating a nerve, which causes sharp pain that radiates down the leg

The best non-diabetic body-composition anchor favors tirzepatide, about 75:25 fat-to-lean loss in its DXA data versus about 62:38 in semaglutides. This is cross-trial evidence, not a head-to-head maintenance-dose DXA result

Studies have shown that tirzepatide helps individuals with diabetes achieve significant weight loss by reducing appetite, enhancing feelings of satiety, and increasing energy expenditure