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A study of nearly 1.1 million people found that semaglutide (the drug in Ozempic and Wegovy) was associated with a 40-70% lower risk of developing Alzheimer's compared to other diabetes medications

Conclusions To conclude, reduced Cmax and delayed tmax of drugs co-administered with GLP1RAs are consistent with the known delayed gastric output by the latter

Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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The science, promise and clinical development of GLP-1 and GIP receptor agonists in obesity