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In the SURMOUNT 1 trial, tirzepatide 15 mg/wk with general nutritional instructions produced a 20.9 % reduction in body weight from baseline (versus 3.1 % with general nutrition instructions alone) [15], whereas in the SURMOUNT 3 trial, tirzepatide 10 or 15 mg/wk started after 12 weeks of intensive lifestyle intervention produced a 25 % reduction from baseline (versus 4.8 % with intensive lifestyle intervention alone) [170]