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Multiple large-scale analyses of observational data, including those comparing GLP-1RAs to SGLT-2 inhibitors and other oral agents, have found no statistically significant association between GLP-1RA use and the exacerbation of DR or the development of sight-threatening retinopathy [9295]

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Ibuprofen, as a non-steroidal anti-inflammatory drug (NSAID), can irritate the stomach lining and increase the risk of gastric ulcers, especially with prolonged use