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GLP-1 also slows digestion and signals satiety to the brain, but is broken down within two minutes
Postmarket Drug Safety Information

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Am J Pathol (2005) 166(2):43342

10.1016/B978-0-12-417150-3.00009-0

[4] reported that the mean WR was 23.4% of maximal weight loss at 7 years after RYGB and that 37% of patients regained more than 25% of their total weight loss