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2 Similarly, Krajewski et al 4 report reductions in HS lesion counts and inflammatory markers such as CRP but emphasize that these are closely linked to metabolic improvements, including weight loss and enhanced insulin sensitivity

A suggested mechanism involves prolonged GIPR agonism causing receptor degradation, reducing sustained GIP signalling and, when combined with GLP-1R agonism, causing increased weight loss ( The GLP-1R has itself several LoF variants including R380C, shown by two independent groups to have normal surface expression but reduced affinity for Exenatide (Wootten et al., 2016

Yue L, Chen S, Ren Q, et al

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"Actually, it involves more work than many were doing even before because now we're sending them to the gym to pick up the dumbbells, to count their protein, to be accountable and do the body composition