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Feb 1995;25(2):155-61

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How Semaglutide Causes Constipation and When It Typically Resolves Semaglutide works by activating GLP-1 receptors in the gut, which slows gastric motility and delays how quickly food moves through your digestive system

Updated 2026-05-25

Others find that staying on the medication sometimes at a lower maintenance dose is what works best for them