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Avoid caffeine and alcohol, as these substances increase urinary fluid loss and can worsen dehydration

Interaction with Blood Thinners Patients who are on anticoagulants like warfarin or direct oral anticoagulants (DOACs) should be aware that semaglutide might amplify the effects of these blood thinners

Diarrhea may settle

The mechanism operates primarily through butyrate production, which acts on receptors that can stimulate GLP-1 secretionthough the magnitude of this effect in humans and whether it translates to meaningful appetite suppression remains unclear

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Most of these events were mild to moderate and concentrated in the first four weeks of each dose escalation, meaning they tended to appear (and resolve) each time the dose increased