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Because the activity drop persists for weeks rather than hours, behavioral changes around eating and energy intake are a plausible driver

GLP-1 drugs seem to fight addiction by reducing the hormone dopamine in a brain system involved in reward, motivation and stress a system "that is co-opted or hijacked, if you will, by addiction," Al-Aly says

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Glucagon acts in the liver via cAMP (Halden et al., 2016)